CRH researcher awarded Eve fellowship to detect early stage ovarian cancer

Dr Neil Ryan, Clinical Lecturer at CRH and IGC, has been awarded an Eve scholarship from The Eve Appeal and North West Cancer Research.

This fellowship aims to create a new blood test to detect ovarian cancer at its earliest stages when it is most treatable.

Finding ovarian cancer early is critical to helping those diagnosed live longer and have more time with their loved ones. Currently, most cases are diagnosed too late, leading to poorer outcomes. Dr Ryan’s research hopes to change this. He plans to look for proteins that are signs of ovarian cancer that can be used as a blood test to pick it up in the earliest stages. 

Receiving the TEA/NWCR Fellowship will allow me to investigate novel markers for the early detection of ovarian cancer, a critical step toward improving outcomes for women. This fellowship not only supports this vital research but also provides invaluable mentorship from two incredible charities, fostering my development as a clinical academic. I am deeply grateful to the donors of these charities, whose generosity makes groundbreaking research like this possible.

There is currently no national screening test for ovarian cancer. If someone goes to the doctor with symptoms that could be caused by ovarian cancer, a blood test will be done to look for CA125, which can be elevated in ovarian cancers. But this test isn’t very specific as high levels of CA125 can be caused by other issues. 

Dr Ryan will look at blood samples from women with early ovarian cancers, healthy women, and women with non-cancerous cysts. He will try find the key proteins in the blood that show up in those with early-stage ovarian cancers. His goal is to create a test that could be widely used by the NHS. 

This Fellowship is part of North West Cancer Research and The Eve Appeal’s commitment to investing in the future, and the brightest minds in gynaecological cancer research. We hope that Neil’s work on ovarian cancer will lead to improvements in early detection, and ultimately, survival rates for women

Neil is the RCOG Subspecialty Trainee in Gynaecological Oncology at the Royal Infirmary of Edinburgh and a Clinical Lecturer at the University of Edinburgh. His PhD at Manchester led to changes in NICE guidelines on womb cancer testing. Neil sits on several national and international committees, including BGCS, EHTG, and Lynch Syndrome UK.

Dr Neil Ryan discusses a journal paper with a colleague
Dr Neil Ryan