Jennifer Brown Research Laboratory. Neuroprotective strategies for babies at risk of brain injury and poor neurodevelopmental outcomes Professor James P Boardman (BSc (hons), MBBS, MSc, PhD, FRCPCH) Professor of Neonatal Medicine Director of the Jennifer Brown Research Laboratory Consultant neonatologist Contact details Website: University Profile Website: Theirworld Edinburgh Birth Cohort website Website: PRENCOG website Email: James.Boardman@ed.ac.uk Research summary Our research aims to improve the lives of children born too soon or too small by finding out how and why preterm birth affects brain development so that we can discover effective ways to promote resilience and improve health outcomes. Research interests Professor Boardman's group contributes to tackling the most significant problem facing 21st-century perinatal medicine: how to reduce brain injury and restore learning potential after preterm birth. He uses neuroinformatic approaches to discover the impact of preterm birth on the developing brain and the biological axes that embed early life adversity in cerebral development. He has built unique infant cohorts phenotyped by structure (brain MRI), biology (immune function, DNA methylation, stress axis activation, gut microbiome), medicine, the social graph, and behaviour, and he has developed tools for integrating multi-scale early life data. Group members Mr Ray Amir, Research Assistant Dr Manuel Blesa Cábez, Postdoctoral Research Fellow Dr Amy Corrigan, Research Midwife Ms Aisling Kenny, PhD student Mrs Jill Hall, Programme coordinator Ms Kirsty Paterson, Research Midwife Dr Melissa Thye, Postdoctoral Research Fellow Dr Kadi Vaher, Postdoctoral Research Fellow Ms Selina Abel, PhD student Dr Fraser Christie, MD student Dr Katie McKinnon, PhD student Miss Rebekah Smikle, PhD student Miss Hannah Smith, PhD student Dr Helen Turner, PhD student Funders Boardman JP and Bogaert D. The gut microbiome in preterm infants: Influencing factors and the association with brain structure and function. University of Edinburgh Wellcome Trust Translational Neuroscience 4-year PhD Programme (108890/Z/15/Z). 2023-2026. Boardman JP, Reynolds RM, Richardson H, Battersby C, Cox SR, Marioni R, Tsanas A, Whalley H, Batty D. Preterm birth as a determinant of neurodevelopment and cognition in children: mechanisms and causal evidence. UKRI MRC Programme Grant (MR/X003434/1), 2023-2027. Boardman JP, Richardson H, Cox SR. The role of perinatal systemic inflammation in brain and cognitive development. University of Edinburgh Wellcome Trust Translational Neuroscience 4-year PhD Programme (108890/Z/15/Z), 2022-2025. Marioni R, Cox S, Boardman JP, Moodie J. Identifying Omics biomarkers of brain health over the life course for early detection of risk of neurological disorders and cognitive decline. University of Edinburgh Wellcome Trust Translational Neuroscience 4-year PhD Programme (108890/Z/15/Z), 2022-2025. Robertson NJ, Hakim-Moulay D, Marlow N, Mitra S, Molloy E, Boardman JP, Standing J, Tranter P, Martinello K, Malhotra A, Allegaert K, Becher JC, Golay X, Boylan G, Jones GR, Walsh B, Hunt R, Kendall G, Miller S, Murray D, Mahaveer AK, Smits A, Pang R. Acute High Dose Melatonin for Encephalopathy of the Newborn (ACUMEN): Phase I Study. MRC Development Pathway Funding Scheme, 2023-2026. Reynolds, RM. Stirrat L, Muray S, Stock S, Boardman JP, Norrie J. Infant hypothalamic-pituitary-adrenal axis responses following antenatal corticosteroids and perinatal outcomes: a mechanism of action of health intervention study. NIHR EME (NIHR133388), 2022-2025. Boardman JP. Theirworld Edinburgh Birth Cohort. Theirworld, 2016-28. Stock SJ, Murray S, Deidda M, Boyd K, Norman JE, Norrie J, Reynolds RM, Boardman JP, Luyt K, Khalil A, Bick D, Reed K, Denton J. A Randomised Placebo-Controlled Trial of Antenatal Corticosteroids for Planned Birth of Twins: STOPPIT-3. NIHR HTA, 2021-25. This article was published on 2024-09-10
